I've used Barnes since 1992 starting with the X, moving on to the XLC and now the TSX and T-TSX. I use them in a 22Hornet (45grXLC), 222mag (45gr XLC), 4 different 243's (85gr TSX and 80gr T_TSX), 2 different 270's (130gr T-TSX), 30-06 (168gr T-TSX), 2 different 300Winmags (168gr TSX and 175gr LRX), 300WSM (168gr TSX) and, finally a 300 Weatherby (180 TSX).
You could say I have a little experience with them.
As has been said, start with a copper free barrel and start at .050 off the lands, then push them hard. In each and every rifle, MOA, or better, is the norm, using the TSX ot T-TSX.
I always start a load at published COL, and, so far, have only had to deviate 2-3 times, most recently with my 30-06 when I switched from the 168gr TSX to the 168gr T-TSX. I had to seat them .010 deeper than the TSX to get sub-MOA.
TheTSX and T-TSX are the easiest to get to shoot well. The early X and XLC's were difficult to get to MOA.
I've seen a noticeable improvement in DRT on big game, (and coyotes using my Hornet), compared to other bullets, and I was a Nosler Partition user since my first big game hunt in 1971. Never had a complaint with a Partition, but the barnes hit harder and are more accurate.
I would expect the GMX from Hornaday and the E-Tip from Nosler to work the same on game as the Barnes.