Case prep can be a massive factor. If you are using brand new brass and want to shrink groups down you can use neolube #2 inside the case necks. Once the cases have been fired try to avoid over cleaning them. Using neolube again will help with second reloading. You can even use graphite powder mixed with alcohol to coat the inside of the necks.
Annealing brass every time will make a huge difference along with learning how to set shoulder back about .002" instead of full resizing.
Another trick that I figured everyone knew was to seat the bullet in about 4 or 5 stages of the handle. In other words press the bullet in a little, then rotate case 180 degrees and seat it a little deeper, then rotate 90 degrees and seat it a little deeper, and go another 180 and seat it all the way. Now this doesn't have to be a super precise protocol. The idea is to spin the round while seating the bullet so that it will correct any out of concentric issues with the die and bullet alignment.
I have also seen seating depth shave almost 2" off of a group so I start with that before I try powder ladder tests.
Lets say that you start with a 2.450" OAL for seating depth. Then try 2.420", 2.390", 2.360", 2.330". I have a 223 that will shoot tiny bugholes at the right OAL. The same combo at different OAL can get up to 2".
Here is a good place to figure out how to get the smallest groups you can get.