H4350 eats barrels in this caliber with heavy bullets, so beware.
I shoot 12 twists with the 60's at 3600-3700 the 55's at 4050, and the 50's at 4150 with Win 760 and Fed 210 primers.
A freind shoots R#15 with the 50's with exceptional accuracy at 3950-4000.
For a while I hunted coyotes in Mexcio with a 27" hart barrel with a 12 twist. My favorite bullet was the 60g Berger at 3700 fps and it shoot a very tiny group with this load of win 760. I actually shot a bob cat in half with the 60g Berger, and it makes some very large holes in coyotes...very humaine.
My fire form load in Rem brass is 39.5g of Win 760 with a fed 210 primer and 55g What ever while killing stuff with 1/2-5/8" groups.
We shot a lot of coytotes with the 55g Sierra BTSp, BTHP, 55g Spt, and 50g Spt, they all just dropped coyotes in their tracks.
The Nosler 60g Partition at 3600 blows some very large holes through deer, just as effective as a 7 Mag.