I was just able to get my 22-250 to shoot after really fighting with it for several months. My best group was with this load:
Remington brass
CCI-200 primers (I want to try the CCI BR's)
36 grains of Varget
52 grain Sierra BTHP
Loading them 0.010" off of the lands.
H-380 is a good choice for powder, but I hear it is kind of dirty.
Depending on the rifle and especially the rate of twist will make the difference on the grain of bullet that it will like; my Rem700 is 1:14" and will not digest anything over 53 grains giving me the accuracy that I demand; and seems to dislike Hornady's for some reason. I got good sub MOA groups out of Berger (35.5 grains of Varget), and even sub MOA out of the Hornady's, but they were a full 1/2" of a wider spread than the Sierra's. Hope this helps.
OH! Moly coated bullets are a pain (JMO).
