2.350 works just fine in 22-250. If you're new to reloading and aren't comfortable with measuring bullets to your specific chamber to be able to ride the rifling, then don't mess with it. 22-250, and 222 rem - are two calibers in particular that just seem to be about perfect at the published OALs. In fact, a lot of people have tried seating long in 22-250 and had their accuracy go to pot on them. So just go with 2.350 and focus more on the other parts of your process, and finding the right charge.