I'm in the process of building a 22-250. I have everything except waiting on the barrel. I'm using a 24" McGowen. It sounds like the 22-250 can have cycling issues and feeding issues. I went with the .100 gas port so I should be able to gas it up if I need to. The case taper is very close to the 22 Nosler which I have no problem with. I guess I'm not afraid of a challenge but have any of you guys built one and had good luck with it.