Kyhowler:
IMO what you need to do is find a buddy with a chronograph and find out exactly how fast your load is in your rifle.
Don't want to get too technical, but then try to find a good ballistics program and plug in the Ballistic Coefficient, and get a trajectory chart for your load.
My .223 40 gr. Nosler Handloads for example, are running 3450 fps,(I average 5 shots). My ballistics program shows I need to sight this load in at 2.4" high at 100 yards. I use the theory of a 6" kill zone, (about the size of a coyote's vitals). With this sight in, my bullet is 3" high at 150 yards, and 3" low at 308 yards. I have a piece of tape on my stock that reminds me the trajectory for that load. I only shoot one load at a time, and if I change loads, I go through the whole process again.
I am also the world's worst at distance judgement, so I convinced my wife I needed a Laser Range Finder for Christmas. I then take readings at various landmarks, fenceposts, cedar trees, etc., and record them in a book. I then refer to them before I hunt the place. This only works if you set up in the same place every time, but the range finder is light, so I sometimes carry it with me if I don't set up in the same place as the last time.
Long answer for a simple question, but I don't feel you know anything until you chrono your loads, then get out and shoot enough to know what that load does at 100 or 200 yards. Sometimes factory velocities are very optimistic, as I have had actually velocities be as much as 150-200 fps less than stated.
Hope this helps!
Tim