it would depend on the type of bullet you're shooting.
if they're just basic lead, or even a copper plated lead bullet, upon firing there's a small splatter of lead that comes out of the end of our bores. said lead, when fired thru a suppressor will eventually build up and potentially fill our cans into a solid lead bar - over the shorter term that buildup will both add weight to your suppressor and reduce its effectiveness as the internal dimensions will be change, which has a direct effect on how the gasses expand through the suppressor.
this is a known issue for rimfire firearms and nearly all of the suppressors commonly used with these calibers are designed to be taken apart for regular cleaning service because of said lead buildup.
now if you were only firing ammo like the hornady vmax or NTX loads, this wouldnt be an issue as these are a proper jacketed or lead free bullet (respectively) and will not deposit lead into your suppressor.
HTH