I have been chronographing loads in my 25-06 A.I. with a couple of different powders. Both RL-17 and RL-22 top out in the high 3500fps range with 100 grain Sierra Match Kings in a 26" 3-groove. I am using Norma brass which is known to be soft compared to Winchester, so I am probably reaching pressure sooner with Norma than I would with Win. brass. So I have some Win brass loaded up to test with Fed-210M primers.
RL-17 hasn't been impressive in the accuracy department with the two bullets I have tried so far, the 95 Berger FB and 100SMK. It has given me the highest velocity so far, I think at 60 grains.
RL-22 has been good in the accuracy department, giving a good combination of velocity in the mid 3500's w/100SMK and accuracy slightly above the .5" mark for 5 shots. I found a load that absolutely bug holes but the velocity is only 3100fps.
59grn RL-19, 95 Berger FB match, Norma 270 brass and a Fed 210M is my varmint/coyote load. I've gotten only one coyote with this load, but it hits like a sledge hammer. I have taken a handful of 500 yard rockchucks and its not as explosive as a V-Max but has adequate terminal capabilities. The load typically shoots 3/8" for 5 shots and its the most consistent and accurate load I've found with this gun. I have some hotter charges than 59grns loaded up and will test those when I get a chance.
Next 25-06 A.I barrel I would like to try a 1-12" twist instead of a 1-10" and maybe even a slightly longer barrel. I don't plan on shooting anything over 100 grains. I hope to shoot the varmint bullets faster.