My 2 cents, I have shot 25-06 for a couple years then stopped because I wanted a.243, both are good, and in a real marksman's hands there are great. I'm average. A frind took my 03-A3 .30-06 and rebarreled it with a stainless steel .25. After a careful break in, I am shooting 1/2" at 200 yds. 75 gr v-max at 3600 fps is a ground hog getter. For deer I use 120 gr factory Fusion, scope readjustment is needed. I would not take a 1000 yd shot at a deer with this, not enough bullet weight. But on young groung hogs at a distance there is no exit hole, I think this will work well on predators that are not in your face when you squeeze off. Long range shots need mass or heavy bullets. The gun smith who worked on my rifle, shoots long range and uses .308 nato, he knows more then I do about this stuff.