Just a note on the 25/300 Weatherby. This would NOT be similar to the 257 Weatherbay or the wildacatts based on the assorted short(standard) mag cases like the 7mm mag, 264, 300Win, etc. This is a full length case and will produce 200-400 fps more speed than the short case, albeit at a higher expense in barrel life and lowder consumption. That is why I included data from my STW as a starting point.
If in fact you were using a 25/300 weatherby, standard 257 weatherby data (And that for it's wildcatt counterparts) might in fact be a dangerous place to start. With the ultra slow powders this round needs to perform; too LITTLE powder can be a dangerous thing. The case capacity of the 257 STW, and a 257/300 Weatherby would be very close. And there is a good deal of data available on the fairly well publicized STW version to work with.
This round and others like it are pretty specialized. But they are fun, fast, and deadly on the critters for which they are best suited. No, there are not efficient. Who cares. If effecient is all that matters, get a 223, a 30-06, a 12 gauge, and a 22 and be done with it. Try not to die of complete efficiency induced boredom.
For those of us who like to occasionally AI something. Or for whom a fast 17 is a joy. Or even those of us who like to occasionally get the snot kicked out of us by some charcoal burning t-rex thumper. Rounds like the 25/300 make perfect sense. Go for it.