Here's my opinion, based on my experience shooting 223 Remington and 17 Remington.
Here are some typical shots I am presented with. Sometimes you can stop them for the shot you want, sometimes you can't control it at all. I prefer to be patient and wait for the right shot opportunity, while my partner just can't stand to wait one second longer and it itching to shoot the first chance he gets. He "misses" frequently. I almost NEVER have a bad shot. I like my way better.
In a perfect world, all shots would be just like this. Put it righ in the crease of their armpit.

This is what many of my shots end up looking like. Quartering towards me. I prefer a neck shot instead of trying to shoot around the femur.

This is not ideal either, because he's blocking his vitals with his leg. Yes I can punch through that bone but I'd rather not. Neck shot!

Same here, if you hit the "elbow" you might not penetrate enough to the vitals. I'd take the neck shot here.

Sometimes this is all you have. The shoulders are pretty much blocking the vitals, so I'd go for the head if I HAD to shoot right now.
