Yes, I have had mine since 1970, or so. I still have 197 rounds of original 38gr Core-Lokt ammo.
It is basically a slightly better round than the 22WMR, mostly because of the Core-Lokt bullet.
Try to keep the range inside of 100yds, if they are facing you, and, maybe add 20-30yds if broadside.
I've only taken a few coyotes with mine, but have shot lot's of other stuff with it.
Do you have the original, Remington-Peters ammo, or the Aguila?
I've not used the Aguila at all, so I can't comment on how that would work on game.