a 6.8SPC is like a mini .270, hits real hard, Glenn G just killed a boar over 300lbs with one of my 6.8's. Great deer gun in my opinion.
6x45 is a great coyote gun and i know lots of killed deer with it, but i would choose something before the 6x45 for deer. Like Venatic said, its cheap to load, uses standard 223 brass.
foot pounds of energy @100yds for each compared to a .223 is:
.223= 1100 with a 55gr bullet
6x45= 1200 with a 75gr bullet
6.8spc=1650 with a 115gr bullet