I'm not using them in a 22-250 but I do use them in my AR in 223. These bullets are very accurate out of my AR. I've smacked several coyotes and none have been able to withstand more than one hit of the 60gr Nosler bt moving at 3,000fps. In my experience, this bullet does hold together better that other varmint bullets. I haven't had any "splashes" however I'm not pushing them at 250 velocities. Overall, I really like this bullet for coyote hunting, but sometimes it's not fur friendly. Side note, I'm currently in the process of a custom 22-250 build with intent of shooting the 60gr Nosler bt.