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I use #4 buck and aim at their neck when broadside. I figured it will hit them in the head and neck and maybe some strays in the chest. I have killed one at 30 yards with #5 turkey loads this way and saw my brother kill one too. It seems a heart lung shot would take a long time to kill a coyote since there is no bullet expansion and shockwave to destroy tissue. Just my 2 cents.