I have not used the 50's in a 22-250, but have shot quite a few of them in the Fiocchi loaded 223's. They shot very well from the gun I was using them in shooting prairie dogs, so I gave them a try on coyotes this past fall. I got several killed with them, had one that I for sure felt should not have got up after having been shot facing dead on at about 60 yards, (got an interesting photo of all that I found of that one), and after skinning a couple I decided to go to a stouter bullet for coyotes. My remaining loads of 50 vmax are gonna go back to killing prairie dogs this summer. What I found when I skinned a handful shot with the vmax was that I wasn't getting enough penetration. Sometimes the hide would be torn up on entry, too, but what got me was the craters just under the hide with bullet fragments in them. It looked to me like the bullets were coming apart before they got into the chest cavity. Yeah, they worked, but for me there are better options for coyotes. Don't think I had any pass throughs with them. Was running them out of a Stag 16" 9 twist AR.
They do shoot sub MOA for me though, and are bad news on littler critters.
