I have had several switch barrel Ruger tang safety and one Mark II. The tang safety were 22/250 AI and 243 AI coyote rifles, and the Mark II is a 6.5x47 Lapua. I also had several Ruger tang safety models in 6 Rem that was rock chuck and p. dog guns.
They shoot great but be aware that if you try to sell them, there is very little demand for a custom Ruger and you will NOT recoup anywhere near as much of your money.
I really love the old Ruger tang safety actions due to the ability to tune the triggers way down, not to mention the tang safety that is right by your thumb.
You hear all kinds of BS on how a Ruger custom will not shoot good, but that is a bunch of nonsense. The quality of barrel, and the quality of how the barrel is chambered is the key, not to mention the quality of the stock.
With the switch barrel 243 AI, I had a McMillen hunter class stock inletted for the Benchrest light varmint contour, 26" barrel with a muzzle break. The barrel was a 12 twist and I was shooting 70g Nosler ballistic tips at 3800. It took a kid 7 shots to get into the Varmint Hunters 1000 yard club that I took p. dog hunting. This old ruger shot three shot groups below .250 with a 12x-32x scope with a tuned trigger of 1 lb, with three inches of the barrel bedded in front of the lug.
Previous to this rifle, I had a coyote rifle built on a Ruger tang safety, with the factory ruger walnut stock opened up for a #5 contour that was 26" long, 12T, Hart SS barrel, zero freebore, 243 Win chamber. This rifle would shoot .250 three shot groups with 80g Sierras at 3400 which was my favorite coyote bullet at the time. 80g Bergers shot just as well in this rifle, but they did not blow big enough holes in the coyotes to suit me, not had the loud, "PLOP" sound that I loved to hear so much.
So, Custom rugers will shoot, but you will suck hind tit when it comes to selling them. As usual, the gunsmith you choose will have a LOT to do with your success.