Many on here like the MPBR concept and while the concept is good, the practice didn't work out well for us. We started using MPBR with our .22-250's and found that we shot over too many coyotes at the 175 yard area particularly. That range is pretty common in our open country. It also about maxes the midrange trajectory when sighted in for MPBR if I remember correctly. A very slight bobble or a slightly high hold and it would cause an over shot coyote.
We have since gone to 200 yard zeros on all our coyote calling rigs. The maximum midrange trajectory is usually less than 1 1/2" and we can still hold right on to 250 yards. That covers about 95% of our calling shots. You'd have to run the numbers for your load, but it will probably still allow you to hold on hair to close to 350. Just our experience. YMMV.
