Bullet design, FPS, twist, shot placement,distance, experience and even age of the shooter all are factors with any bullet.
I don't think I've ever killed a coyote or fox that was not a poly or HP tipped bullet. If I have it was only one or 2 at most.
Head shots are not the best choice for the average hunter/shooter. Heck there are plenty that can not get the shot correct on the vitals of a broadside coyote.