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I haven't had very good luck with the 50gr. V-Max. I lost a coyote using American Eagle 50gr. Varmint tipped bullets which is what they call a V-Max I guess. I shot it a few times and it still managed to get away. I switched to Fiocchi 50gr. V-Max and had to shoot a coyote 3 times to kill it. I know that's not very many but I don't keep using a bullet if I get a repeat in bad performance. I've had a pretty good track record with the 55's. Out of a 22-250 the 50's might do fine though.