I asked this exact question about a week or two ago for my new 22-250. I got alot of responses, and here is what I did, and Im happy with my results.
First, clean it real good before shooting it.
Then, go out and shoot as your sighting it in. I cleaned after the first ten rounds and then after every 20 until it found the load it liked. Now I clean after every time at the range or in the field, or after every 20-25 rounds (whichever comes first)
I shoot factory ammo, and realized it does take about 75 rounds before you can start to get a group that is satisfactory (atleast to me). I have put 95 rounds through it now and with factory loads, and just yesterday finally got it to shoot sub 1" at 100. I think it will get even more accurate after another 50 loads or so, but I am very happy.
So as far as the break in process, you will find an equal number of guys who follow a strict program, and those that say just shoot and clean when your done. I think both groups of folks can probably get about the same group at the range, and as long as it is a clean barrel, and you don't allow copper build up. Basically if your looking for a certain response to justify a pattern you want to follow, you will find it here. Congrats on a new toy and have fun with it.
