I've used the MPBR concept all of my shooting life. I understood it and applied it while still a child. For my coyote rigs, I use a 4" MPBR, which for my current hot rods equates to being zeroed at about 300 yards and MPBR's out to about 350. At 100, they are between 1.5 and 1.75 inches high. This allows me to use the same sight picture from the muzzle to ~350 yards, and basically still holding on fur at 400. If a coyote is far enough away that I need to start thinking about adjusting my aim for hold over, I usually start thinking about simply not taking the shot instead.
A .270 has a rainbow trajectory by comparison of course, but the first several hundred coyotes I killed were all with a .270, using the exact same 4" MPBR zeroing technique. The point blank range was just a lot shorter than the stuff I use these days. I used 110's in my .270 back then and zeroed at 225 for an MPBR around 275 yards. Which, meant zeroing about 1.75" high at 100.
Site height plays a role in these calculations, obviously.
Use whatever approach to zero that works for ya, but do understand what you are using and why. It helps.
- DAA