When i calibrate a reticle to the trajectory of my load i always use the optics highest power, no matter what reticle i am using. I then run a ballistics program for my load and test 3 different points along the trajectory, especially x-hair zero. Usually the ballistics program is close. If not i calculate MOA error at each range, then go back to the ballistics program and change BC +/or muzzle velocity to get a closer match to the true trajectory. I then calculate reticle zeros in 25 or 50-yd. increments only. Here's an example. Suppose i have a Ball. Plex reticle on a gun. I know that at the optic's highest power the 2nd and 3rd subtension r 4.5 and 7.5 IPHY respectively. If say my 425 yd. trajectory is 6.2 IPHY below x-hair zero then i subtract 4.5 from 6.2 and that's 1.7 IPHY. Now there is 3.0 IPHY between #2 and 3. So if i divide 1.7 by 3.0 that's 0.6. Now the entry on my range sticker for that range is 2.6. Now do the same for windage, and u'll have an interpolative grid established that will allow for the most accurate system of reference for that reticle vs. trajectory.
There is some viability to adjusting subtension by adjusting the power in 2nd focal plane reticles, and that may be a better way to go. All one needs do is calculate and establish x-hair zero. Now shoot the zeros at 300, 400 and 500 yds.--even 600 if the reticle goes that far. Now calculate the drop at all the ranges in MOA, and mark each MOA zero on the 100 yd. tgt. Look at it with your reticle and adjust the power until the stadia lines line up as close as possible paying particular attention to the longer ranges. That's the "abbreviated intuitive 2nd focal plane reticle zeroing system"...sort of.
Burris has done a great job of describing the systems in the above noted links.