The easiest most effective round to load for is the 6x6.8 hands down when you factor in component availability. 6dti if you want to fireform to get things exact.
As far as 22 cal the 22 Nosler is gonna be the easiest and probably the fastest.
Don't forget to take into consideration the available twist rates and freebore so it's somewhat optimized for the bullets weights that you want to shoot.
