The time to change calibers depends on a couple of things, same primer size is pretty quick, probably around 10 minutes if you have a powder measure preset for the correct charge, 20 minutes if you have to change primer sizes.
How long to change a powder charge is dependent on pure luck, sometimes you can dial it right up, sometimes you have to go looking for it, that's why it pays to have more than 1 powder measure, you can have the other one preset for the charge you need.
With all the supplies where I can reach them, and primer tubes loaded, I can comfortably run somewhere between 400 to 500 rounds per hour, if I really pushed it I might be able to beat that, but the normal pace is fine for me. (RL550)
Bottleneck rifle calibers are a completely different animal, they require processing, so the reloading is done in two different sections, clean cases are lubed, sized, trimmed, and deburred, cleaned to remove lube, then stored ready to load. When I'm ready to load 223, I pull out the processed cases, and run them through the Dillon, I reprime the cases in station 1, load powder in station 2, seat bullet in station 3, and then a slight taper crimp at station 4.
Dillon owns the progressive reloader market, that wasn't given to them, they earned it.