I had a puppy once that had distemper. Its mother was not vaccinated. The pup started having siezures. The vet said it could be epilepsy, so we put the dog on meds, but the siezures continued. Eventually, we hit the point where any higher dosage would damage the dog's organs, and the siezures weren't stopping, so we had to put the dog down. Too bad too, because a simple vaccination to the mother would have prevented a lot of sad hearts.