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It depends on what you're hunting and the caliber you're using but I've quit using MPR for coyotes. For the .22 centerfires we had too many misses at 175 yards which is close to maximum midrange trajectory. That range is a pretty common shot where we call predators. The slightest bobble upwards would cause a miss. That being said, I beleive a longer sight-in would be a benefit to you without getting into midrange misses. MPR says to sight-in a .22-250 at about 250 yards if I remember correctly. I now sight in my calling rifles at 200 yards. The midrange misses have ceased but I still have a longer "hold dead on" range than when sighting in at 100. Long story short--there is probably a happy medium between the MPR listed in ballistic charts and a 100 yard zero. JMHO.