True Mr. Cronk, I was speaking in terms of a 4" (+ or -) MPBR trajectory, i.e., a big game rifle. Nevertheless, the problem I have had with this type of zero is germane. The point of the MPBR trajectory is to maximize your rifles range (of a specific game) and eliminate the need for hold over or under out to that range. The price paid for the extended range without hold over is placing the apex of your trajectory (whatever the apex may be) at an earlier point. Speaking generally, I don't want the the point of trajectory with the highest calculated error to be at the range I expect to shoot most of my game. As I tried to point out, this is the case for me.
I shoot most of my field mice between 100 and 200 yards, so I find it impractical to sight in my mouse rifle for MPBR for field mice because it then shoots 1" high at 150 yards. So if I'm off 1/2" I shoot high. I suspect your mouse hunting in Iowa differs from the conditions I have in Idaho so the MMPBR (maximum mouse point blank range) method may work well for you. Moose is another story. I have yet to hunt mice or moose in Iowa, if I do maybe I'll rezero my rifles.