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I had a pair of Great Pyrrenese that were hell on coyotes, ofcourse my male wieghed 184lbs and had a mane around its neck that I could barely wrap my arms around. If he caught'em they were stone dead.
Chupa
If I remember correctly, some time in the liniage of the Great Pyrrenese, they were bread for similiar purposes. I have seen many ranchers that have this breed exactly for that reason. They are one domestic breed that can kill coyotes lickity split. The Airdale Terrier is another that comes to mind. Most domestic dogs are out gunned by a Coyote that makes his living dealing out death.
