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In the .223,  H-335  is safe, safe, safe as long as you stay within the load amount reocmmendations for the 40 gr. bullet,.........H-4198 is also good for 40 Gr. bullets..I have shot several thousand P/Dogs with H-335 and 40 Gr. V-Max bullets and never had any problems...Just stay within the recommended load range and you'll be fine...