This whole business of determining what is a safe place to start with a given bunch of components is probably one of the most confusing issues a new reloader has to address. The idea is, first and foremost, that you don't want to exceed the maximum safe peak operating pressure for your particular rifle/cartridge combination. Now consider all the things that affect that pressure: different lots of the same powder can vary in burning rate; different bullets of the same weight can effect pressure according to the particular jacket material used, the length of the bearing surface of that particular design, and the jacket thickness. Case capacity affects pressure: all other things being equal a lower capacity case gives greater pressure with the same powder charge than does a case of higher capacity. Different primers can give different pressures. The configuration of your rifle's throat can affect pressure, as can the depth your bullet is seated. The distance your bullet travels before engaging the rifling affects pressure. The amount your rifle bore deviates above or below the nominal size and the rate of rifling twist affect pressure. Here's my system for determining a starting load. Knock on wood, in thirty six years of reloading I've never destroyed a rifle or had a reloading-caused mishap. First, get multiple sources for data. Get at least a couple of bullet manufacturers' manuals. I use Sierra and Nosler. Also get all the powder manufacturer's manuals you can lay your hands on. A reliable internet source is loaddata.com, by Wolfe Publishing. Most of the manufacturers have data available on line as well. If I can find a load listed in a reputable source that uses all the exact same components I'm using, powder, bullet, primer and case, I drop ten percent and start there. If I can't find an exact match I look at all the combinations I can find for that weight bullet and that particular powder. I throw out any that are real high or real low, average the rest and start ten percent below that average. I start with my bullet seated .050 off the lands or at the maximum length that will work through the magazine, whichever is shorter. In other words, if a load that is .050 off the lands is too long to work through the rifle's magazine, I seat it in until the loaded round will work through the magazine. I only load a couple of rounds to start and usually fire them outside my shop to see if I have any signs of excessive pressure. If not, I load three rounds each of five loads, increasing the powder charge in half grain increments. These I take to the range and starting with the lowest powder charge, shoot for accuracy and velocity over my chronograph. When I get to a point where I've hit near the average top velocity for that bullet/powder combination in one or more of my (reliable) data sources, or when I start seeing excessive pressure signs, I quit. If I hit the speed I want and get the accuracy I want, life is good. If not I start trying some tuning, usually involving cartridge overall length. Anymore that doesn't often seem necessary in a good rifle. Now the question is, what are excessive pressure signs? As has been mentioned, hard bolt lift is one. If you've got a bright spot on your case head where the brass extruded back into the ejector hole or slot in the bolt face, then was scrubbed off when the bolt was turned, you are on the brink of disaster. Likewise if your primer is really flattened out, filling the primer pocket to the edges and has the machining marks of the bolt face imprinted in it. If your chronograph is showing significantly higher velocity than the max load listed in your data sources for that weight bullet in that cartridge you are pushing pressures too high as well. It's a good idea to stick with powders that, over the years, the reloading community has determined are a good match with the cartridge and bullet weight you're reloading. Also keep in mind, you can't change the laws of physics. If you're getting a significantly increased velocity over the maximums listed for a particular bullet weight in a particular cartridge, you are running at significantly increased pressure. You can do this in a rifle for a while without things coming apart, but you're stressing the rifle beyond its design parameters and eventually someone has to pay the piper. Pick your way along carefully. Knowledge is your best defense. Learn everything you can as you go along. Learn from reputable sources. Be especially careful of advice you get on internet forums. There are a lot of good people online who can give you a lot of help, but honestly, some of the stuff I see promulgated by some of the self professed internet experts is downright scary. Good luck.