We started using muzzle breaks in the early 80's to help us see our hits on chucks and p. dogs. Even a 243 hot loaded is a [beeep] cat with a break, and you can see your hits clearly instead of just seeing dust fly. We got to where we could place our shots on the animal instead of just holding center of mass.
Then I put them on my 22 ppc, 6ppc, and 6 BR that are benchrest rifles. I was able to reduce the size of my groups by about half.
Next, I put them on my 270, 30/06,7 Mag...good gosh, no one would believe that standard factory sporters would shoot groups as tiny as these rifles shoot.
So, 22/250's, 22/250 AI, 243, 243 AI's, 244 AI's, and the custom 7 STW, all get the same threads for the muzzle break, just screw them on one barrel to the other.
The bullet is still in the barrel for about .200 while the gun is under recoil, less recoil, more accuracy. I also think that shooter fatigue is much less, and critical gun hold, cheek pressure, hand grip is much less critical if you have a muzzle break installed. Muzzle breaks will not help a guy that slaps the trigger
Problem is that shooters are deceived into thinking that they can shoot a gun without ear protection with no muzzle break and not experience hearing losss. So, when you increase the noise with a muzzle break, you should wear ear protection. I wear the Tac 6 eletronic ear muffs...love'em! None the less, shooting rifles, shotguns, and pistols without ear protection is self destructive...your choice...hearing or no hearing later on in life.
In my experience, in shooting any caliber in any weight gun including the 22/250's and larger calibers, adding a muzzle break enables me to shrink my groups substantially.
Some posters commented on taking the muzzle break on and off as to whether you would help/hurt accuracy. You work up a load with the muzzle break installed on the gun. In my experience, adding the weight to the barrel has always helped shoot very tiny groups....I have a few very large and heavy muzzle breaks that have 3 expansion chambers and 132 holes, of two different sizes.
Imagine shooting a 7 Mag with a 140g bullet at 3250 fps, you fire, at the shot, you see the water vapor fly off the deer's hide, and see the deer flop. Or imagine seeing a buck hit at 325 yards, he jumps 10 feet straight up and hits the ground with his antlers stuck in the ground. Imagine seeing a bull elk running broadside to you, you hit him with the 7 mag right behind the shoulder. At the shot, the bull sticks his tongue out 12", his front legs quits working, and you see his nose plow the ground. You simply do not see this kind of bullet impacts when you do not have a muzzle break.
To each is own