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I've hunted coyotes for years with muzzleloaders because of my writing and often coyotes were the only game available when rifles came in.  I really prefer Hornady .45 caliber 260 grain hollow points in black MMP sabots shot through a .50 caliber muzzleloader.  Any accurate powder charge from 85 to 110 grains will do.  I most often use a Traditions Pursuit Pro with a 3-9X40mm scope and very seldom shoot with magnification above 3X.  My most common powder charge in that rifle is two Triple 7 50-grain pellets and the rifle will consistently group inside of two inches at 100 yards.  I sight in 2" high at 50 yards and am pretty much dead on out to 120 yards.  You don't need premium bullets for coyotes and you need to develop your most accurate load.  I normally use shooting sticks and take along a pump shotgun for close range shots but in areas where only shotguns and muzzleloaders are allowed this combo works very well.


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