Like the Master Gunny said,
MY opinion,
Get a good reloading manual,
read it thoroughly;
Keep it simple...
Pick one powder,
one primer,
one bullet,
one type brass,
Start at Book COAL.
Adjust loads for best groups,
then adjust COAL.
Some 22-250's actually like a bit of a jump to the lands.
If none of this works, you can ask for a refund for what you paid for this advice.