I've owned 4 22-250's and currently still have a modified Rem 700 VLS and a Kimber 84M Classic. The best groups I ever got from any of my rifles was with Winchester brass, CCI 200 primer, Benchmark and a Nosler 55 grain BT. All rifles have a 14 twist. Out of the VLS this load shoots one very small hole at 100 yards.
I have a policy of not giving the powder charge on the net so you'll have to start low and work up.
