I was in the same predicament a while back when I started loading for a .22-250. For powders I tried H380 and Varget. For bullets I've tried Nosler 50 gr BT, 55 gr Hornady Vmax, Nosler 55 gr BT and Sierra 52 gr match.
H380 is a horrible powder for use in OH if you shoot the rifle year round. It's just to temperature sensitive.
Then I tried Varget. I found so many differences in my loading manuals that I was ready to try another powder. But I worked up loads with the Varget anyway.
I couldn't get the 50 gr Nosler to shoot accurately. I don't know if it's the powder or the gun. The 55 gr Hornady was OK at best. The surprise was the 52 gr with Varget, this one shoots! I worked up loads and found 36.5 gr of Varget accurate but velocity over a chrono was only 3440 fps. So I kept going. At 38.0 gr I hit on a load just as accurate as 36.5 gr but now the bullet was moving at 3700 fps. The 38.0 gr load is in my lyman book. There are no signs of high pressure either, primers even look fine.
Found the same problem with Varget in my .308, I can't hit the velocity that is advertised unless I go with 1.5 to 2.0 gr more.
I now have a rifle that shoots 1 load accurately, I'm no longer a fan of the .22-250. This is a cartridge that has humbled me after 34 years of reloading. If I seat the bullet out any further then what is listed as max in my manuals accuracy falls apart. Would you believe 3" groups?
Good luck on your pursuit of a good load.
