If you can get them to shoot well I'd try them. I shoot cheap Speer 52gr HPs out of my 22-250 and they work. The bad thing about experimenting is with a runner you don't recover you never know if it was the shooter or the bullet.
Last week I saw a coyote shot a 50 yards and the bullet hit just a little far back, nearly eviscerated the coyote guts and liver hanging out of the exit and the coyote got up and started to move off another to the head finished him. Another few feet and the coyote would have made it into the brush and we wouldn't have known if it was the bullet or the shooter.
I've killed a lot of coyotes with the old 222.Rem and tend to feel most runners are shooter related if shooting a bullet designed for the rifle... I personally feel fast twist barrels and light bullets are a recipe for bullet failure and speed is less influential than twist. I shoot the same 52gr Speer my 222 Rem, 223, 5.6x50R Mag, 22-250 and 22-250AI all slow twist and it performs well.