I have a vortex viper 6.5-20x44 on my 250 and it is a lot of scope but I have never really had a problem with close shots on the low end but can see where it could be a problem. One of the coyotes we shot last week was shot by my buddy with the same scope on his 25-06 at 30 yds and had no issue but the coyote also did the textbook broadside stop and pose. It does get a bit tougher when you have to follow them at that magnification if they won't stop. As far as the reticle, I have found myself using the regular duplex because I can't recall a time I needed or even tried one of the BDC reticles. With how flat the 22-250 shoots, you can sight in at 200, hold on the top of the back at three hundred, and after that start spinning knobs. Too much clutter on the BDC style but I also won't pass them up if I find a good deal on them. If I replaced the 6.5-20 on my 250, I think I would likely try the 3.5-14x40 or 4.5-18x40 Nikon Prostaff 5...both seem like a real usable mag range especially for the 22-250 and I have taken a liking to Nikon scopes. Just my opinion.
