I think it depends a lot on the kind of country you hunt, and the distances you shoot coyotes. I prefer to sight in using the maximum point blank method, and do any allowing for shooting high at the closer ranges. For instance, in order to be dead on at 330 yds, I need to be about 2 1/2 inches high at 100, which makes it about 3 1/4" high at mid range. I can allow for that a lot easier at relatively close range to be able to hold dead on at 300 to 330 yds. It all gets down to your personal preference. A good rangefinder sure helps too, as I proved when hunting with Jerry Hunsley in S. Dakota. My new Bushnell combo binocular/range finder was not functioning, and I misjudged a big male to be 300 yds, and he was actually over 350. As a result, I gave him a good dirt bath. I was holding dead on his shoulder and should have been high on his shoulder. I loaded the 80 grain Sierra Blitz Varminter and killed well over 200 coyotes with this sighting in method. I switched to the 70 grain Sierra Blitz King when it came out and it is a flatter shooting bullet. I didn't change any of my sight in elements though, as they only changed at extremely long range, indicative of this projectile being more efficient in the wind, etc.. I have yet to have one get up and run at all when this 70 grain Blitz King hits him in his boiler room. If I was hunting country with a lot more thick weeds and brush, I would probably go for more extreme accuracy up to 200 yds. Hope this helps you. Your particular rifle may not function like mine, which is another consideration. I shoot a Browning A-bolt 243 Silent Stalker with a 4 x 14 Bushnell Scopechief, and the BOSS system.