i smoke. i try to mask it as much as possible. i'll have a smoke after i finish a stand. then i'll spray my clothes down with scent killer, hat, gloves, etc. I use some skin lotion by Dead Down Wind for my face and hands. It's some pretty good stuff and goes along way toward freshing up. But I don't ignore the wind. I enter my hunting areas with the wind to my face, try to set up on a cross wind, or use my ecaller and set up downwind. I mist my stand area and caller/decoy area with fox, bobcat and rabbit urine. Wear rubber boots.
if you pay attention to the wind you can still be successful. i'm having a decent year here in alabama. 4 yotes and a nice gray fox so far. i've been busted several times for moving, but i usually don't see the ones that wind me i guess.