shadowhunter, good question. Forget the 22. LR you can do much better with subsonic loads in the 223rem. I help out with predator controll and some of the places we shoot are down town in the center of town. I use silencers on all centerfire guns, they are truly silent when used with subsonic loads. A good choice is 45gr or 50gr bullets. Serria, nosler, hornady all wok great. The powders I would use are Allirnt bullseye,allient red dot, hodgdon clays or hodgon tightwad. For 40gr bullets use 4grs as a starting load and go down from there untill you are subsonic. For 50 gr bullets use start with 5gr and go down from ther untill youe are subsonic. My killing load is 4.5gr of hodgdon tightwad, and a speer 50gr tnt bullet. Plenty of power it will shoot through a 4x4 poast at 25 yards so be sure of your back stop. Make sure your gun is 100% cleen and you lube the bore with a good lube prior to shooting, breake free works for me.