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I have shot a pickup truck and traler load of deer with that exact set up. I have used the sierra accuracy load of 39.0 grains of H322 a federal 215 primer and a 200 grain round nose to kill white tails out to 200 yards. I have also killed deer withb 158 and 180 grain jacketed hollow points from my Father in Laws 35rem. Try to neck size or your brass is only good for 4 shots. When you can see a ring form about an inch above the rim in the web area toss it out. You bought the perfect hunting handgun. Wear ear protection or you will have Tenitis.