I have shot a lot of IMR 4350 and 4831 in 25/06's in earlier years. I shot the barrels out of two rifles shooting jackrabbits years ago.
Later on, I met a gunsmith in TExas that turned me on to the Reloader series of powders.
My load with R#19 is as follows:
Win Brass only in all of these loads:
100g Speer BTSP
Win Large Rifle Primer
57-58.5g of R#19 (depending on the lot#)
velocity is outstanding in the 3450 fps
Accuracy is 1" at 200 yards with a sporter weight rifle
100g NOsler B.T.
63.0g of R#25
Fed 215 Primer
Velocity is 3520 fps
Accuracy is 1 1/2" at 300 yards
115g Nosler BT
58.0g of R#25; this is a max load in my rifle at 70*
Fed 215 Primer
Velocity is 3350
Accuracy is 5/8" at 100 yards
Back off these loads and work up these loads in your rifle due to variations in lot# of powder and differences in rifles.
Good luck!