On a well made scope, you will normally see very little or no change in POI with a power change. However, if your requirements require the utmost in precision, even with a cheap scope, sight it in with the power setting you are most likely to be using for hunting purposes .....and leave it there.
The only way you will know for certain if the POI will change with a power change is to shoot the gun at one setting, then do the same at the other setting.
