If you want to shoot the 63g Sierra Semi point, the 1-14 twist will stabalize them just fine.
Also, if you are building a custom gun, the 22/250 AI is a WHALE of a yote rifle!
A 24" #4 is a perfect walk about rifle that you may need on longer shots, and will give you a rigid barrel for super accuracy and speed.
If you wanted to go a little faster twist, then the 1-12 will handle the 60g Nosler partitions,60g Hornady V max, and the mighty 60g Berger perfectly.