You can't kill 'em too much. I've done most of mine with a .270, 130 gr bullet, but they almost always ran some before dropping. I'm going this month in So. Tex, and am going to use the .270 in a 150 gr. Nosler Partition. I think that will probably anchor most of them.
A friend of mine hit a big boar 2 years ago with a .308 through both lungs. It still ran 200 yds and took almost half a day to track in heavy cover.
Hogs are big-boned animals, so if you're a good shooter and a head shot presents itself then that's what I'd do. I just purchased a .300 win mag for an Alaska hunt this summer and am considering taking it along on the hog hunt to get some trigger time with it.