Sometimes Ackley Improved cartridges make sense. It is a lot easier and cheaper to come up with 22/250 AI brass than it is 220 Swift brass (by fireforming factory ammo in the 22/250 AI chambered gun).
Many people buy guns because they want to be unique. Do we really need any hunting cartridges besides 30/06 and .375 H&H? Well, not really, as they will do anything they need to. So why do we have the 50+ or so cartridges we do, people just want something else!
I came across a 1910 Mexican Mauser, what to do with it? It is now a 257 AI. Nice shooting gun and it was my first foray into wildcat chamberings. It has a certain rightness about that cartridge in a gun with a 3" magazine box.
Aaron