Yes. On all my calibers from med-heavy barrels. I see a POI (on/off) shift of 2-4" (elevation/windage) depending on the rifle. Most shoot the best groups with the suppressor on, however, I have a couple rifles that shoot 1/2" tighter with it off.
Now if you mean, sighting my rifles in using the same can, ammo, etc. and then removing for days, weeks, and/or months and re-attaching it, then I have seen no shift (I also load development with the can on).
I leave my cans on for months and have never noticed condensation of any kind.
My recommendation is do your own testing and see how your firearms will perform with/without.
