What ackman said is correct. You can also take a magic marker or Sharpie and paint the bullet. once you chamber the round like he said, the lands will mark the bullet you will know exactly where the bullet hits the lands. and you will know the seating depth.
the 22-250 is NOT Finicky, you will find all kinds of powder to use.
You HAVE to find out what YOUR rifle likes. I will give you some examples of powder that works good. Varget, IMR 4895, IMR 8208, H380 especially with a 50gr Nosler or Hornady. 4064 can work too, But another bullet is Sierra. Nosler edges out the Hornady in my gun. NOW,,, Sometimes things work a little better if you back off the max charges. I am not taking anything away from what everyone has told you. BUT lets not get the cart before the Horse. First work on some loads and then after you get a decent group start TWEAKING it with seating depth, and even 1 tenth of a grain up or down. If you go 3 tenths each way that is enough. And how far you are shooting is going to have some bearing upon things. Remember this,, Once you get everything clicking your way,,, 1" group at 3oo yds ? then you should be able to make a hit at 1000yds One step at a time here. You will make it.